{"id":7541,"date":"2021-02-23T14:54:16","date_gmt":"2021-02-23T11:54:16","guid":{"rendered":"https:\/\/locus-medicus.gr\/dna-fragmentation\/"},"modified":"2022-08-01T14:51:59","modified_gmt":"2022-08-01T11:51:59","slug":"dna-fragmentation","status":"publish","type":"page","link":"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/","title":{"rendered":"DNA Fragmentation &#038; Sperm Oxidative Damage"},"content":{"rendered":"<p>[vc_row full_width=&#8221;stretch_row&#8221; background_color=&#8221;custom&#8221; custom_background_color=&#8221;#222222&#8243;][vc_column]\n\t\t\t<!-- START DNAfragmentation REVOLUTION SLIDER 6.3.3 --><p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t<rs-module-wrap id=\"rev_slider_53_1_wrapper\" data-source=\"gallery\" style=\"background:transparent;padding:0;margin:0px auto;margin-top:0;margin-bottom:0;\">\n\t\t\t\t<rs-module id=\"rev_slider_53_1\" style=\"\" data-version=\"6.3.3\">\n\t\t\t\t\t<rs-slides>\n\t\t\t\t\t\t<rs-slide data-key=\"rs-105\" data-title=\"Slide\" data-anim=\"ei:d,d,d;eo:d,d,d;s:d,d,d,d;r:0,0,0;t:curtain-1,curtain-3,curtain-2,random-selected;sl:d,d,d,d;\" data-rndtrans=\"on\" data-mediafilter=\"slumber\" data-p1=\"01\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"\/\/locus-medicus.gr\/wp-content\/uploads\/2021\/09\/dna-fragmentation3sm.jpg\" title=\"dna-fragmentation3sm\" width=\"1920\" height=\"1300\" class=\"rev-slidebg\" data-no-retina>\n<!--\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-53-slide-105-layer-0\" \n\t\t\t\t\t\t\t\tdata-type=\"shape\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"xo:132px,96px,72px,44px;yo:299px,218px,165px,101px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:20,14,10,6;l:0,18,13,8;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:10px,7px,5px,3px;h:168px,122px,92px,56px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"st:700;sp:1500;sR:700;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:6800;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:10;background-color:#4ba6b4;\"\n\t\t\t\t\t\t\t> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-53-slide-105-layer-1\" \n\t\t\t\t\t\t\t\tdata-type=\"text\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-xy=\"x:l,c,c,c;xo:152px,0,0,0;y:m;yo:66px,-28px,-28px,-10px;\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:60,60,45,30;l:60,67,50,34;fw:300,700,700,700;a:left,center,center,center;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:548px,817px,620px,380px;h:auto,135px,auto,auto;\"\n\t\t\t\t\t\t\t\tdata-frame_0=\"y:50px;\"\n\t\t\t\t\t\t\t\tdata-frame_1=\"st:700;sp:1500;sR:700;\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:6800;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:9;font-family:Roboto;\"\n\t\t\t\t\t\t\t>DNA Fragmentation<br\/>& Sperm Oxidative Damage\n\n \n\t\t\t\t\t\t\t<\/rs-layer><!--\n\n\t\t\t\t\t\t\t--><rs-layer\n\t\t\t\t\t\t\t\tid=\"slider-53-slide-105-layer-2\" \n\t\t\t\t\t\t\t\tdata-type=\"shape\"\n\t\t\t\t\t\t\t\tdata-rsp_ch=\"on\"\n\t\t\t\t\t\t\t\tdata-text=\"w:normal;s:20,14,10,6;l:0,18,13,8;\"\n\t\t\t\t\t\t\t\tdata-dim=\"w:100%;h:100%;\"\n\t\t\t\t\t\t\t\tdata-basealign=\"slide\"\n\t\t\t\t\t\t\t\tdata-frame_999=\"o:0;st:w;sR:8700;\"\n\t\t\t\t\t\t\t\tstyle=\"z-index:8;background-color:rgba(0,0,0,0.2);\"\n\t\t\t\t\t\t\t> \n\t\t\t\t\t\t\t<\/rs-layer><!--\n-->\t\t\t\t\t\t<\/rs-slide>\n\t\t\t\t\t<\/rs-slides>\n\t\t\t\t<\/rs-module>\n\t\t\t\t<script type=\"text\/javascript\">\n\t\t\t\t\tsetREVStartSize({c: 'rev_slider_53_1',rl:[1240,1024,778,480],el:[630,900,800,700],gw:[1400,1024,778,480],gh:[630,600,400,300],type:'standard',justify:'',layout:'fullwidth',mh:\"930\"});\n\t\t\t\t\tvar\trevapi53,\n\t\t\t\t\t\ttpj;\n\t\t\t\t\tfunction revinit_revslider531() {\n\t\t\t\t\tjQuery(function() {\n\t\t\t\t\t\ttpj = jQuery;\n\t\t\t\t\t\trevapi53 = tpj(\"#rev_slider_53_1\");\n\t\t\t\t\t\tif(revapi53==undefined || revapi53.revolution == undefined){\n\t\t\t\t\t\t\trevslider_showDoubleJqueryError(\"rev_slider_53_1\");\n\t\t\t\t\t\t}else{\n\t\t\t\t\t\t\trevapi53.revolution({\n\t\t\t\t\t\t\t\tsliderLayout:\"fullwidth\",\n\t\t\t\t\t\t\t\tvisibilityLevels:\"1240,1024,778,480\",\n\t\t\t\t\t\t\t\tgridwidth:\"1400,1024,778,480\",\n\t\t\t\t\t\t\t\tgridheight:\"630,600,400,300\",\n\t\t\t\t\t\t\t\tminHeight:930,\n\t\t\t\t\t\t\t\tspinner:\"spinner3\",\n\t\t\t\t\t\t\t\tperspective:600,\n\t\t\t\t\t\t\t\tperspectiveType:\"local\",\n\t\t\t\t\t\t\t\teditorheight:\"630,900,800,700\",\n\t\t\t\t\t\t\t\tresponsiveLevels:\"1240,1024,778,480\",\n\t\t\t\t\t\t\t\tprogressBar:{disableProgressBar:true},\n\t\t\t\t\t\t\t\tnavigation: {\n\t\t\t\t\t\t\t\t\tonHoverStop:false\n\t\t\t\t\t\t\t\t},\n\t\t\t\t\t\t\t\tfallbacks: {\n\t\t\t\t\t\t\t\t\tallowHTML5AutoPlayOnAndroid:true\n\t\t\t\t\t\t\t\t},\n\t\t\t\t\t\t\t});\n\t\t\t\t\t\t}\n\t\t\t\t\t\t\n\t\t\t\t\t});\n\t\t\t\t\t} \/\/ End of RevInitScript\n\t\t\t\tvar once_revslider531 = false;\n\t\t\t\tif (document.readyState === \"loading\") {document.addEventListener('readystatechange',function() { if((document.readyState === \"interactive\" || document.readyState === \"complete\") && !once_revslider531 ) { once_revslider531 = true; revinit_revslider531();}});} else {once_revslider531 = true; revinit_revslider531();}\n\t\t\t\t<\/script>\n\t\t\t\t<script>\n\t\t\t\t\tvar htmlDivCss = '\t#rev_slider_53_1_wrapper rs-loader.spinner3 div { background-color: #FFFFFF !important; } ';\n\t\t\t\t\tvar htmlDiv = document.getElementById('rs-plugin-settings-inline-css');\n\t\t\t\t\tif(htmlDiv) {\n\t\t\t\t\t\thtmlDiv.innerHTML = htmlDiv.innerHTML + htmlDivCss;\n\t\t\t\t\t}else{\n\t\t\t\t\t\tvar htmlDiv = document.createElement('div');\n\t\t\t\t\t\thtmlDiv.innerHTML = '<style>' + htmlDivCss + '<\/style>';\n\t\t\t\t\t\tdocument.getElementsByTagName('head')[0].appendChild(htmlDiv.childNodes[0]);\n\t\t\t\t\t}\n\t\t\t\t<\/script>\n\t\t\t<\/rs-module-wrap>\n\t\t\t<!-- END REVOLUTION SLIDER -->\n[\/vc_column][\/vc_row][vc_row lg_spacing=&#8221;padding_top:145;padding_bottom:145&#8243; sm_spacing=&#8221;padding_top:100;padding_bottom:100&#8243;][vc_column offset=&#8221;vc_col-md-4&#8243;][tm_heading style=&#8221;highlight&#8221; custom_google_font=&#8221;&#8221; google_fonts=&#8221;font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal&#8221; text=&#8221;In addition to the age of the woman, the male factor plays an equally important role in the cases of karyotypically abnormal fetuses.&#8221; font_size=&#8221;sm:24;md:30;lg:36&#8243; line_height=&#8221;1.42&#8243;][tm_spacer size=&#8221;sm:40&#8243;][\/vc_column][vc_column offset=&#8221;vc_col-md-offset-1 vc_col-md-7&#8243;][tm_heading custom_google_font=&#8221;&#8221; google_fonts=&#8221;font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal&#8221; text=&#8221;DNA Fragmentation &amp; Sperm Oxidative Damage&#8221; font_size=&#8221;lg:18&#8243; line_height=&#8221;1.39&#8243;][tm_spacer size=&#8221;lg:20&#8243;][tm_heading tag=&#8221;div&#8221; custom_google_font=&#8221;&#8221; google_fonts=&#8221;font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal&#8221; text=&#8221;Apart from the age of the woman, the male factor plays an equally important role in the cases of karyotypically abnormal fetuses. In everyday practice, we encounter cases even with normal parameters of the sperm diagram, where the sperm DNA has lesions that in the literature are largely related to the creation of genetically problematic embryos.<br \/>\nThe genetic integrity of the sperm is assessed by the DFI sperm analysis using the Flow Cytometry \/ TUNNEL assay and is necessary for the development of the normal fetus. The fragmentation of genetic material in the sperm undermines significantly the chance of a successful pregnancy and increases the risk of miscarriage, regardless the way of conception (i.e. naturally or through assisted reproduction), thus causing male infertility. In addition, due to the limited levels of antioxidant defense and a unique, limited mechanism for detecting and repairing DNA damage, sperm is particularly vulnerable to oxidative stress.<\/p>\n<p>The 8\u2013OhdG sperm test allows the calculation of the levels of 8\u2013OHdG (8\u2013hydroxy\u2013deoxyguanosine) which is a by\u2013product of DNA degeneration due to oxidative stress and is detected by flow cytometry inside the sperm. Oxidative stress is a major cause of defective sperm function that causes DNA damage, in addition to fragmentation, and is thus associated with male infertility or miscarriages.&#8221; font_size=&#8221;lg:18&#8243; line_height=&#8221;1.62&#8243;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<\/p>\n<p class=\"p1\">However, according to the above information on the changes in the sperm DNA, it should be taken into consideration that we do not cite these two types of sperm damage as causes of infertility and relapses. It is more practical to consider these lesions as the result of more central causes, such as chronic inflammation of the male genital tract, or habits such as smoking or substance use, or conditions, such as obesity, varicose veins or various endocrine or metabolic diseases. After all, in many cases, these DNA lesions disappear permanently or for long periods. Thus, by measuring the DNA damages, vital information can be taken on whether to proceed to the assisted reproduction or whether these should be corrected first.<\/p>\n<p class=\"p1\">Woman\u2019s age must always be considered. After all, we all need to be reminded that the concerned part is the couple and not each individual alone. It should be noted that the role of eggs (ova), in addition to the structural involvement of the zygote is to correct the sperm\u2019s DNA lesions, since mature spermatozoa have reduced DNA repair capacity. We therefore emphasize that the corrective capacity of the eggs (ova) decreases with woman\u2019s age. So, as we can not increase the egg\u2019s repair capacity, we must offer the woman the best possible sperm DNA quality, regardless of the reduced corrective abilities of the female\u2019s gametes. We know that if genetic abnormalities of the zygpte are not corrected, then cell divisions are not promoted and this is another dimension in genetic causes, beyond the pathology of karyotypes.<\/p>\n<p>[\/vc_column_text][tm_spacer size=&#8221;lg:50&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_image image_size=&#8221;custom&#8221; align=&#8221;right&#8221; sm_align=&#8221;center&#8221; image=&#8221;6403&#8243; image_size_width=&#8221;745&#8243; image_size_height=&#8221;680&#8243;][tm_spacer size=&#8221;sm:50&#8243;][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; content_placement=&#8221;middle&#8221; background_color=&#8221;primary&#8221; lg_spacing=&#8221;padding_top:69;padding_bottom:69&#8243;][vc_column width=&#8221;1\/2&#8243;][tm_heading custom_google_font=&#8221;&#8221; xs_align=&#8221;center&#8221; text_color=&#8221;custom&#8221; custom_text_color=&#8221;#ffffff&#8221; text=&#8221;Book your appointment today&#8221;][tm_spacer size=&#8221;xs:30&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_button button=&#8221;url:tel%3A00302106544444|title:%2B30-210%2065%2044%20444&#8243; align=&#8221;right&#8221; xs_align=&#8221;center&#8221; color=&#8221;custom&#8221; button_bg_color=&#8221;custom&#8221; font_color=&#8221;primary&#8221; button_border_color=&#8221;custom&#8221; custom_button_bg_color=&#8221;#ffffff&#8221; custom_button_border_color=&#8221;#ffffff&#8221;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row full_width=&#8221;stretch_row&#8221; background_color=&#8221;custom&#8221; custom_background_color=&#8221;#222222&#8243;][vc_column][\/vc_column][\/vc_row][vc_row lg_spacing=&#8221;padding_top:145;padding_bottom:145&#8243; sm_spacing=&#8221;padding_top:100;padding_bottom:100&#8243;][vc_column offset=&#8221;vc_col-md-4&#8243;][tm_heading style=&#8221;highlight&#8221; custom_google_font=&#8221;&#8221; google_fonts=&#8221;font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal&#8221; text=&#8221;In addition to the age of the woman, the male factor plays an equally important role in the cases of karyotypically abnormal fetuses.&#8221; font_size=&#8221;sm:24;md:30;lg:36&#8243; line_height=&#8221;1.42&#8243;][tm_spacer size=&#8221;sm:40&#8243;][\/vc_column][vc_column offset=&#8221;vc_col-md-offset-1 vc_col-md-7&#8243;][tm_heading custom_google_font=&#8221;&#8221; google_fonts=&#8221;font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal&#8221; text=&#8221;DNA Fragmentation &amp; Sperm Oxidative Damage&#8221; font_size=&#8221;lg:18&#8243; line_height=&#8221;1.39&#8243;][tm_spacer size=&#8221;lg:20&#8243;][tm_heading tag=&#8221;div&#8221; custom_google_font=&#8221;&#8221; google_fonts=&#8221;font_family:Open%20Sans%3A300%2C300italic%2Cregular%2Citalic%2C600%2C600italic%2C700%2C700italic%2C800%2C800italic|font_style:300%20light%20regular%3A300%3Anormal&#8221; text=&#8221;Apart from the age of the woman, the male factor plays an equally important role in the cases of karyotypically abnormal fetuses. In everyday practice, we encounter cases even with normal parameters of the sperm diagram, where the sperm DNA has lesions that in the literature are largely related to the creation of genetically problematic embryos. The genetic integrity of the sperm is assessed by the DFI sperm analysis using the Flow Cytometry \/ TUNNEL assay and is necessary for the development of the normal fetus. The fragmentation of genetic material in the sperm undermines significantly the chance of a successful pregnancy and increases the risk of miscarriage, regardless the way of conception (i.e. naturally or through assisted reproduction), thus causing male infertility. In addition, due to the limited levels of antioxidant defense and a unique, limited mechanism for detecting and repairing DNA damage, sperm is particularly vulnerable to oxidative stress. The 8\u2013OhdG sperm test allows the calculation of the levels of 8\u2013OHdG (8\u2013hydroxy\u2013deoxyguanosine) which is a by\u2013product of DNA degeneration due to oxidative stress and is detected by flow cytometry inside the sperm. Oxidative stress is a major cause of defective sperm function that causes DNA damage, in addition to fragmentation, and is thus associated with male infertility or miscarriages.&#8221; font_size=&#8221;lg:18&#8243; line_height=&#8221;1.62&#8243;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_column_text] However, according to the above information on the changes in the sperm DNA, it should be taken into consideration that we do not cite these two types of sperm damage as causes of infertility and relapses. It is more practical to consider these lesions as the result of more central causes, such as chronic inflammation of the male genital tract, or habits such as smoking or substance use, or conditions, such as obesity, varicose veins or various endocrine or metabolic diseases. After all, in many cases, these DNA lesions disappear permanently or for long periods. Thus, by measuring the DNA damages, vital information can be taken on whether to proceed to the assisted reproduction or whether these should be corrected first. Woman\u2019s age must always be considered. After all, we all need to be reminded that the concerned part is the couple and not each individual alone. It should be noted that the role of eggs (ova), in addition to the structural involvement of the zygote is to correct the sperm\u2019s DNA lesions, since mature spermatozoa have reduced DNA repair capacity. We therefore emphasize that the corrective capacity of the eggs (ova) decreases with woman\u2019s age. So, as we can not increase the egg\u2019s repair capacity, we must offer the woman the best possible sperm DNA quality, regardless of the reduced corrective abilities of the female\u2019s gametes. We know that if genetic abnormalities of the zygpte are not corrected, then cell divisions are not promoted and this is another dimension in genetic causes, beyond the pathology of karyotypes. [\/vc_column_text][tm_spacer size=&#8221;lg:50&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_image image_size=&#8221;custom&#8221; align=&#8221;right&#8221; sm_align=&#8221;center&#8221; image=&#8221;6403&#8243; image_size_width=&#8221;745&#8243; image_size_height=&#8221;680&#8243;][tm_spacer size=&#8221;sm:50&#8243;][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; content_placement=&#8221;middle&#8221; background_color=&#8221;primary&#8221; lg_spacing=&#8221;padding_top:69;padding_bottom:69&#8243;][vc_column width=&#8221;1\/2&#8243;][tm_heading custom_google_font=&#8221;&#8221; xs_align=&#8221;center&#8221; text_color=&#8221;custom&#8221; custom_text_color=&#8221;#ffffff&#8221; text=&#8221;Book your appointment today&#8221;][tm_spacer size=&#8221;xs:30&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_button button=&#8221;url:tel%3A00302106544444|title:%2B30-210%2065%2044%20444&#8243; align=&#8221;right&#8221; xs_align=&#8221;center&#8221; color=&#8221;custom&#8221; button_bg_color=&#8221;custom&#8221; font_color=&#8221;primary&#8221; button_border_color=&#8221;custom&#8221; custom_button_bg_color=&#8221;#ffffff&#8221; custom_button_border_color=&#8221;#ffffff&#8221;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7660,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-7541","page","type-page","status-publish","hentry","post-no-thumbnail"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.4.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>DNA Fragmentation &amp; Sperm Oxidative Damage - Locus Medicus<\/title>\n<meta name=\"description\" content=\"In addition to the age of the woman, the male factor plays an equally important role in the cases of karyotypically abnormal fetuses.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DNA Fragmentation &amp; Sperm Oxidative Damage - Locus Medicus\" \/>\n<meta property=\"og:description\" content=\"In addition to the age of the woman, the male factor plays an equally important role in the cases of karyotypically abnormal fetuses.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/\" \/>\n<meta property=\"og:site_name\" content=\"Locus Medicus\" \/>\n<meta property=\"article:modified_time\" content=\"2022-08-01T11:51:59+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Organization\",\"@id\":\"https:\/\/locus-medicus.gr\/#organization\",\"name\":\"Locus Medicus\",\"url\":\"https:\/\/locus-medicus.gr\/\",\"sameAs\":[],\"logo\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/locus-medicus.gr\/#logo\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/locus-medicus.gr\/wp-content\/uploads\/2021\/02\/locus-logo.png\",\"contentUrl\":\"https:\/\/locus-medicus.gr\/wp-content\/uploads\/2021\/02\/locus-logo.png\",\"width\":553,\"height\":199,\"caption\":\"Locus Medicus\"},\"image\":{\"@id\":\"https:\/\/locus-medicus.gr\/#logo\"}},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/locus-medicus.gr\/#website\",\"url\":\"https:\/\/locus-medicus.gr\/\",\"name\":\"Locus Medicus\",\"description\":\"\u0394\u0399\u0391\u0393\u039d\u03a9\u03a3\u03a4\u0399\u039a\u039f \u039a\u0395\u039d\u03a4\u03a1\u039f | \u03a5\u03a0\u039f\u0393\u039f\u039d\u0399\u039c\u039f\u03a4\u0397\u03a4\u0391 | \u0398\u03a1\u039f\u039c\u0392\u039f\u03a6\u0399\u039b\u0399\u0391 - \u039a\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae - \u039a\u03b1\u03c1\u03c5\u03cc\u03c4\u03c5\u03c0\u03bf\u03b9\",\"publisher\":{\"@id\":\"https:\/\/locus-medicus.gr\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/locus-medicus.gr\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/#webpage\",\"url\":\"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/\",\"name\":\"DNA Fragmentation & Sperm Oxidative Damage - Locus Medicus\",\"isPartOf\":{\"@id\":\"https:\/\/locus-medicus.gr\/#website\"},\"datePublished\":\"2021-02-23T11:54:16+00:00\",\"dateModified\":\"2022-08-01T11:51:59+00:00\",\"description\":\"In addition to the age of the woman, the male factor plays an equally important role in the cases of karyotypically abnormal fetuses.\",\"breadcrumb\":{\"@id\":\"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u0391\u03c1\u03c7\u03b9\u03ba\u03ae\",\"item\":\"https:\/\/locus-medicus.gr\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Special Examinations (Man)\",\"item\":\"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"DNA Fragmentation &#038; Sperm Oxidative Damage\"}]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"DNA Fragmentation & Sperm Oxidative Damage - Locus Medicus","description":"In addition to the age of the woman, the male factor plays an equally important role in the cases of karyotypically abnormal fetuses.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/","og_locale":"en_US","og_type":"article","og_title":"DNA Fragmentation & Sperm Oxidative Damage - Locus Medicus","og_description":"In addition to the age of the woman, the male factor plays an equally important role in the cases of karyotypically abnormal fetuses.","og_url":"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/","og_site_name":"Locus Medicus","article_modified_time":"2022-08-01T11:51:59+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Organization","@id":"https:\/\/locus-medicus.gr\/#organization","name":"Locus Medicus","url":"https:\/\/locus-medicus.gr\/","sameAs":[],"logo":{"@type":"ImageObject","@id":"https:\/\/locus-medicus.gr\/#logo","inLanguage":"en-US","url":"https:\/\/locus-medicus.gr\/wp-content\/uploads\/2021\/02\/locus-logo.png","contentUrl":"https:\/\/locus-medicus.gr\/wp-content\/uploads\/2021\/02\/locus-logo.png","width":553,"height":199,"caption":"Locus Medicus"},"image":{"@id":"https:\/\/locus-medicus.gr\/#logo"}},{"@type":"WebSite","@id":"https:\/\/locus-medicus.gr\/#website","url":"https:\/\/locus-medicus.gr\/","name":"Locus Medicus","description":"\u0394\u0399\u0391\u0393\u039d\u03a9\u03a3\u03a4\u0399\u039a\u039f \u039a\u0395\u039d\u03a4\u03a1\u039f | \u03a5\u03a0\u039f\u0393\u039f\u039d\u0399\u039c\u039f\u03a4\u0397\u03a4\u0391 | \u0398\u03a1\u039f\u039c\u0392\u039f\u03a6\u0399\u039b\u0399\u0391 - \u039a\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae - \u039a\u03b1\u03c1\u03c5\u03cc\u03c4\u03c5\u03c0\u03bf\u03b9","publisher":{"@id":"https:\/\/locus-medicus.gr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/locus-medicus.gr\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/#webpage","url":"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/","name":"DNA Fragmentation & Sperm Oxidative Damage - Locus Medicus","isPartOf":{"@id":"https:\/\/locus-medicus.gr\/#website"},"datePublished":"2021-02-23T11:54:16+00:00","dateModified":"2022-08-01T11:51:59+00:00","description":"In addition to the age of the woman, the male factor plays an equally important role in the cases of karyotypically abnormal fetuses.","breadcrumb":{"@id":"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/dna-fragmentation\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u0391\u03c1\u03c7\u03b9\u03ba\u03ae","item":"https:\/\/locus-medicus.gr\/en\/"},{"@type":"ListItem","position":2,"name":"Special Examinations (Man)","item":"https:\/\/locus-medicus.gr\/en\/eidikes-exetaseis-andras\/"},{"@type":"ListItem","position":3,"name":"DNA Fragmentation &#038; Sperm Oxidative Damage"}]}]}},"_links":{"self":[{"href":"https:\/\/locus-medicus.gr\/en\/wp-json\/wp\/v2\/pages\/7541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/locus-medicus.gr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/locus-medicus.gr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/locus-medicus.gr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/locus-medicus.gr\/en\/wp-json\/wp\/v2\/comments?post=7541"}],"version-history":[{"count":3,"href":"https:\/\/locus-medicus.gr\/en\/wp-json\/wp\/v2\/pages\/7541\/revisions"}],"predecessor-version":[{"id":7811,"href":"https:\/\/locus-medicus.gr\/en\/wp-json\/wp\/v2\/pages\/7541\/revisions\/7811"}],"up":[{"embeddable":true,"href":"https:\/\/locus-medicus.gr\/en\/wp-json\/wp\/v2\/pages\/7660"}],"wp:attachment":[{"href":"https:\/\/locus-medicus.gr\/en\/wp-json\/wp\/v2\/media?parent=7541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}