Other Menstrual Tissue Tests (3 or 18 in1)

Menstruation tissue testing (such as the Hidden-C Test) apart from detection of Chlamydia, can also be used for Mycoplasma hominis and Ureaplasma urealyticum testing in period tissue (menstrual blood). State of the art Real Time PCR testing offers extreme sensitivity and specificity for the detection of these microorganisms compared to conventional testing such as cervical fluid cultures etc.

Furthermore, as the sample can be self-collected at home, it is not necessary to visit a clinical facility or employ the help of a medical professional for specimen collection (of course your clinician should be advised for result interpretation and therapy).


Triple Μycoplasma-Ureaplasma-Chlamydia detection test in mestrual tissue:

  • Μycoplasma hominis
  • Ureaplasma urealyticum
  • Chlamydia trachomatis

Apart from Chlamydia, the endometrium is also susceptible to infections by microorganisms such as Mycoplasma and Ureaplasma, while Ureaplasma in particular has been associated with spontaneous abortions (miscarriage). Moreover, Mycoplasma and Ureaplasma originating at the prostate can adversly effect both sperm number and motility, while Chlamydia from sperm cells can be vertically transmitted to the embryo which may lead to recurrent abortions of immunological etiology (for more information see SPI test). We believe that the presence of Mycoplasma and especially Ureaplasma should be investigated and if found, should be treated in both male and female partners at the same time.


18 in 1 test - Detection panel of Sexually transmitted microorganisms in 1 sample ( PCR/DNA Microarrays):

  • Chlamydia trachomatis
  • Chlamydiaceae spp.
  • Ureaplasma urealyticum
  • Mycoplasma hominis
  • Mycoplasma genitalium
  • Neisseria gonorrhoeae
  • Herpes simplex 1
  • Herpes simplex 2
  • Treponema pallidum
  • Haemophylus ducreyi
  • Trichomonas vaginalis
  • Candida albicans
  • Candida dubliniensis
  • Candida parapsilosis
  • Candida tropicalis
  • Candida glabrata
  • Candida krusei
  • Candida guilliermondii

Microorganisms such as Mycoplasma and Ureaplasma originating at the prostate can severely decrease sperm number and motility. Moreover, the endometrium is also susceptible to infections while Ureaplasma in particular has been associated with spontaneous abortion (miscarriage). We believe that the presence of Ureaplasma should be investigated in every case and that it should be treated in both male and female partners at the same time.

According to researchers, viral infections and their resulting immunological complications are implicated in more than 80% of subfertile couple cases.

The majority of causes for subfertility of immunological etiology can be attributed to viral infections of the female partner as we have shown in two scientific paper publications on the American Journal of Reproductive Immunology  on 2004 and 2005 (more information on Locus Medicus research can be found here).

Specifically, the presence of a particular group of viruses, the Herpesviridae family of DNA viruses or herpesviruses (including Herpes Simplex Virus 1 and 2 which are responsible for most cold sores and most genital herpes cases respectively) has been identified as one of the main causes of elevation of blood levels of Natural Killer Lymphocytes (NK cells). These cells have been found elevated in women with a history of infertility of unknown etiology. More than 50% of women with a history of infertility of unknown etiology are showing high NK blood concentration according to our research (Michou V.I.et.al. (2003). Fertil Steril., 80 Suppl 2:691-7 , Locus Medicus Laboratory, Athens, Greece).It seems that in the majority of cases the NK increase was associated with the presence of herpesviruses in the blood of these women. 

The problem of herpesviruses infection can be easily dealt with through the administration of proper anti-viral treatment. Indeed, when our research team identified the association of viral infections with infertility, a large number of couples facing this kind of problem, achieved their goal (conception and birth) after very simple antiviral treatment.

Up until recently, conventional methods of viral infection detection exhibited low sensitivity. However, the development of highly sensitive PCR (polymerase chain reaction) -based detection methodology revealed a much higher prevalence of viral infection than originally thought. 

Using state-of-the-art techniques, detection of virtually any microorganism is possible (bacteria, viruses or fungi) through our tests. The question is, which pathogens are of clinical significance in any given medical case such as subfertility, STD screening, endometritis etc. Our new “17 in 1” test that can detect 17 sexually transmitted microorganisms in the same sample, including Chlamydia, Mycoplasma, Ureaplasma and Herpesviruses 1/2 can be used for diagnosis of all three of the above clinical questions.