ypogonhmothta-xrwmoswmikos-elegxos-andra Chromosomal and
Genetic Control of Man

The presence of micro-deficiencies in the Y chromosome and mutations in the cystic fibrosis gene are important genetic factors for male infertility.

Chromosomal and Genetic Control of Man

Εκτός από τους επίκτητους λόγους που δειλά αρχίζουν να υπονοούνται και να παρουσιάζονται κυρίως πίσω από τον κατακερματισμό του DNA των σπερματοζωαρίων προς το παρόν, πρέπει να αναφερθούν και οι κληρονομούμενοι λόγοι που οδηγούν σε υπογονιμότητα.

In addition to the acquired reasons that are timidly beginning to be implied and presented mainly behind the fragmentation of sperm DNA at present, the inherited reasons that lead to infertility must also be mentioned.

Karyotypic abnormalities of prospective parents with chromosomal permutations or other related lesions are an important part of the couple's investigation into both a history of infertility and spontaneous miscarriages. The pre–implantation of the embryos with a process of assisted reproduction is usually recommended to in these couples, in order to exclude the abnormal embryos.

For male infertility, apart from the chromosomal abnormalities and DNA problems of the first embryonic cell generations, other important genetic factors involved are the presence of micro-deficiencies on the Y chromosome (particularly common in cases of azoo– / oligospermia) and the mutations of the cystic fibrosis gene (CFTR), which are mainly associated with cases of obstructive azoospermia.

We consider the information on the risk of transmission of Y chromosome abnormalities and of cystic fibrosis very important. In the first case, the male offspring acquired through IVF will definitely have fertilization problems just like his father, while in the case of cystic fibrosis, a specific investigation procedure must be followed.

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